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Resurface and rebuild, in fewer sessions.
A smarter alternative to microneedling with PRP or exosomes. Our Helix CoolPeel fractional CO2 laser paired with Ariessence Pure PDGF+, the only FDA-approved growth factor in aesthetics, delivers real texture, tone, and collagen results, with no blood draw.
If you have been exploring skin resurfacing options, you have likely come across microneedling with PRP or exosomes. These treatments have built a loyal following, and for good reason. But a newer combination is now turning heads in medical aesthetics, and it is winning on nearly every front.
CoolPeel laser resurfacing paired with Ariessence Pure PDGF+ offers something blood-based and exosome treatments cannot promise: consistency, purity, and pharmaceutical-grade predictability, every single time.
It is a treatment protocol backed by clinical data rather than marketing trends, and it delivers two things at once: real resurfacing of the skin’s surface plus deep collagen stimulation, in fewer sessions and with no blood draw. A consultation is required before treatment so we can assess your skin and build the right plan.
What the treatment combines
What is CoolPeel?
CoolPeel is a fractional CO2 laser treatment using our Helix device that resurfaces the outermost layers of skin with precision. Unlike older ablative lasers that required weeks of downtime, CoolPeel delivers controlled columns of laser energy to target sun damage, fine lines, uneven texture, and enlarged pores, while leaving surrounding tissue intact for faster healing.
Most clients see redness for one to two days and return to normal activities quickly.
What is Ariessence Pure PDGF+?
Ariessence Pure PDGF+ is the first and only aesthetic product containing an FDA-approved growth factor, platelet-derived growth factor (PDGF). This is not a trend ingredient or an unregulated extract. PDGF has been used in four FDA-approved medical treatments over 28 years, with more than 5.5 million patients treated.
Ariessence uses recombinant technology to produce a sterile, pharmaceutical-grade version of the exact growth factor naturally found in human blood and platelets. The formula contains just four ingredients: water, sodium acetate, hyaluronic acid, and sh-polypeptide-59 dimer (pure PDGF). No unknowns, no fillers, no guesswork. At Renew MedSpa, Ariessence has replaced PRP, PRF, and exosomes after resurfacing procedures.
Resurfacing and repair, working together
CoolPeel creates precise microchannels in the skin, temporarily opening pathways that let topical actives absorb far more deeply than they would on intact skin.
Deep delivery
When Ariessence PDGF+ is applied immediately after treatment, it penetrates directly to the level where collagen-producing fibroblasts live, delivering the growth factor exactly where it is needed.
Accelerated repair
PDGF signals those fibroblasts to accelerate tissue repair, produce new collagen, and reduce inflammation, which is exactly what you want after resurfacing.
Faster healing
The result is faster healing and reduced redness duration compared to laser alone. Many clients notice tighter, more hydrated skin within 72 hours.
Results that build
Improvements in texture and tone continue to build for up to six months as new collagen matures, so your skin keeps getting better after treatment.
Why not just microneedling with PRP or exosomes?
Microneedling with PRP relies on your blood being drawn, spun in a centrifuge, and reapplied to your skin. The result depends entirely on the quality and composition of your blood that day. Stress, hydration, age, and medications all affect your platelet count and growth factor levels, so you might get a great result one session and a weaker one the next, through no fault of the treatment itself.
Exosomes, while promising in research, are currently unregulated in the aesthetics market. The source, purity, and growth factor concentration vary widely from brand to brand and batch to batch. There is no standardization, and the FDA has raised concerns about unapproved exosome products used in aesthetic procedures.
Ariessence eliminates both problems. It delivers the same pharmaceutical-grade potency in every single vial, because it is made in a lab, not extracted from blood or biologics.
How the options compare
| Feature | CoolPeel PDGF | Microneedling + PRP | Microneedling + Exosomes |
|---|---|---|---|
| Blood draw required | No | Yes | No |
| Growth factor consistency | Same every session | Varies by patient | Varies by batch or brand |
| FDA standing | FDA-approved growth factor | Procedure, not product | Unregulated in aesthetics |
| Ingredient transparency | 4 known ingredients | Variable blood composition | Unknown number of components |
| Resurfacing and repair together | Yes, CO2 plus PDGF | Surface only, no resurfacing | Surface only, no resurfacing |
| Downtime | 1 to 2 days typical | 1 to 3 days | 1 to 3 days |
| Sessions typical | 1 to 3 sessions | 3 to 6 sessions | 3 to 6 sessions |
| Collagen timeline | Up to 6 months building | 3 to 6 months building | Variable |
Microneedling remains a treatment we offer. CoolPeel PDGF is simply a more targeted, efficient choice for many resurfacing goals.
CoolPeel resurfaces and rebuilds at the same time. Microneedling only rebuilds. Same recovery, more results, fewer appointments.
If your concerns include texture, pore size, sun damage, fine lines, or dull tone, CoolPeel is the more targeted and efficient choice. It resurfaces the outer skin layer while stimulating deep collagen, two jobs in one treatment, while microneedling triggers healing but leaves surface damage untouched.
Who the CoolPeel PDGF treatment is for
- Fine lines, sun damage, enlarged pores, or uneven texture, the core concerns CoolPeel resurfacing addresses.
- Early signs of skin laxity, where collagen stimulation makes a visible difference over time.
- Undereye crepiness, fine lines around the eyes, or loose eyelid skin, delicate areas that microneedling simply cannot treat.
- Anyone wanting real results without extended downtime, and a protocol backed by clinical data rather than marketing trends.
- All skin types. The Helix platform lets our providers customize settings for every Fitzpatrick skin type safely, a meaningful difference from older CO2 lasers.
Most clients complete one to three sessions spaced four to six weeks apart, with results that continue to develop over the months following the final session.
Your treatment, step by step
A consultation and skin assessment come first. We review your concerns and medical history and build a personalized plan, typically one to three sessions, four to six weeks apart.
Topical numbing
A topical anesthetic is applied to the treatment area for about 30 minutes before we begin, for a comfortable experience.
CoolPeel resurfacing
The fractional CO2 laser passes over the skin, creating precise microchannels that stimulate natural repair and address texture, tone, and fine lines. Most people feel only slight warmth.
Ariessence PDGF+
Immediately after the laser, Ariessence Pure PDGF+ is applied. The open microchannels allow deep absorption, delivering PDGF to the fibroblasts where it signals collagen production and repair.
CoolPeel PDGF treatment options
CoolPeel + PDGF
- CoolPeel fractional CO2 resurfacing
- Ariessence Pure PDGF+ application
- Best for first-time clients or a one-time refresh
Series of 3
- 3 CoolPeel sessions, spaced 4 to 6 weeks
- Ariessence PDGF+ at each session
- Personalized treatment plan
- Recommended for optimal collagen remodeling over 4 to 6 months
CoolPeel PDGF FAQ
CoolPeel is a fractional CO2 laser that simultaneously resurfaces the outer skin layer and stimulates deep collagen. Microneedling creates micro-injuries in the dermis to trigger healing, but does not resurface the surface, so it cannot directly address sun damage, rough texture, or enlarged pores the way CoolPeel can. Most clients need one to three CoolPeel sessions versus three to six with microneedling, with comparable one to two day downtime.
No. Unlike PRP and PRF, CoolPeel with Ariessence PDGF+ requires no blood draw at all. Ariessence is a pharmaceutical-grade growth factor made in a controlled lab, containing the same platelet-derived growth factor naturally found in your blood but produced for consistent potency in every vial. That means shorter appointments and no variability based on your blood that day.
PDGF stands for platelet-derived growth factor, a naturally occurring protein that signals the body to produce new collagen, repair tissue, and reduce inflammation. Ariessence contains an FDA-approved form of PDGF, the first of its kind in aesthetics. The same growth factor has been used in four FDA-approved medical products over 28 years. Applied immediately after CoolPeel, it penetrates deeply through the open microchannels and accelerates collagen building.
Exosomes are promising in research but currently unregulated in aesthetics, with source, purity, and concentration varying widely between brands and batches. The FDA has raised concerns about unapproved exosome products for aesthetic use. Ariessence contains a single, known, FDA-approved growth factor produced in a pharmaceutical-grade lab with the same concentration in every vial, four ingredients and a 28-year safety record behind the active ingredient.
Most clients experience one to two days of mild redness and warmth, comparable to microneedling. Many resume normal activities within 24 hours. We recommend avoiding direct sun and following the post-care protocol provided at your appointment. Ariessence PDGF+ may also help reduce redness duration by accelerating repair.
Most clients complete one to three sessions spaced four to six weeks apart, depending on their concerns and goals. A single session can produce meaningful improvement in texture, tone, and radiance. A series of three is recommended for more significant concerns like deeper sun damage, fine lines, or acne scarring, as collagen remodeling continues to build for up to six months after the final session.
Yes. CoolPeel at Renew MedSpa is safe for all skin types and tones. We use the Helix platform, which gives our providers precise control over settings, so we tailor every treatment to your specific skin tone and reduce the risk of irritation or pigmentation changes that can be a concern with older CO2 technology. We assess your skin at your consultation and build a plan that fits you.
Yes, and this is one of the biggest advantages over microneedling. The Helix CO2 laser can safely and precisely treat the undereye and eyelid areas, targeting crepiness, fine lines, and loose skin in zones where needles cannot safely be used. Our providers dial in the exact depth and density for the delicate skin around the eyes, delivering real improvement with just one to two days of downtime.
Many clients notice improved hydration and radiance within 72 hours as the skin heals. More significant improvements in texture, firmness, and tone develop over the following four to six weeks as new collagen matures. With a full series of three, results continue to build for up to six months after the last treatment.
Ready to experience the difference?
Real resurfacing plus deep collagen repair, in fewer sessions and with no blood draw. Book an appointment, and your provider will assess your skin and build a plan around your goals.
