CoolPeel PDGF Treatment

A smarter alternative to microneedling with PRP or exosomes, with fewer sessions and no blood draw

The Helix CoolPeel fractional CO2 laser resurfacing treatment combined with Ariessence PDGF+, the only FDA-approved growth factor in aesthetics, delivers real texture, tone, and collagen results, without blood draws or unpredictable outcomes.

• No blood draw
• FDA-approved growth factor with pharmaceutical-grade purity
• Minimal downtime

Why the CoolPeel PDGF Treatment is the new gold standard in skin rejuvenation

If you’ve been exploring skin resurfacing options, you’ve likely come across microneedling with PRP or exosomes. These treatments have built a loyal following, and for good reason. But a newer combination is now turning heads in the medical aesthetics world, and it’s winning on nearly every front.

CoolPeel laser resurfacing paired with Ariessence Pure PDGF+ offers something that blood-based and exosome treatments simply can’t promise: consistency, purity, and pharmaceutical-grade predictability, every single time.

What is CoolPeel?

CoolPeel is a fractional CO2 laser treatment using our Helix device that resurfaces the outermost layers of skin with precision. Unlike older ablative lasers that required weeks of downtime, CoolPeel delivers controlled columns of laser energy to target sun damage, fine lines, uneven texture, and enlarged pores, while leaving surrounding tissue intact for faster healing. Most clients see redness for 1-2 days and return to normal activities quickly.

What is Ariessence Pure PDGF+?

Ariessence Pure PDGF+ is the first and only aesthetic product containing an FDA-approved growth factor, platelet-derived growth factor (PDGF). This isn’t a trend ingredient or an unregulated extract. PDGF has been used in four FDA-approved medical treatments over 28 years, with more than 5.5 million patients treated. Ariessence uses recombinant technology to produce a sterile, pharmaceutical-grade version of the exact same growth factor naturally found in human blood and platelets. The formula contains just four ingredients: water, sodium acetate, hyaluronic acid, and sh-polypeptide-59 dimer (pure PDGF). That’s it. No unknowns, no fillers, no guesswork.

At Renew MedSpa, Ariessence has replaced PRP, PRF, and exosomes after microneedling and other laser procedures. It is powerful, more predictable, and extremely easy to use.

Why not just do microneedling with PRP or exosomes?

Microneedling with PRP relies on your blood being drawn, spun in a centrifuge, and then reapplied to your skin. The result depends entirely on the quality and composition of your blood that day. Stress, hydration, age, and medications all affect your platelet count and growth factor levels. You might get a great result one session and a weaker one the next, through no fault of the treatment itself.

Exosomes, while promising in research, are currently unregulated in the aesthetics market. The source, purity, and growth factor concentration of exosome products vary widely from brand to brand and batch to batch. There is no standardization, and the FDA has raised concerns about unapproved exosome products being used in aesthetic procedures.

Ariessence eliminates both problems. It contains up to 300,000 times the growth factor concentration of comparable applications, and it delivers the same potency in every single vial, because it’s made in a lab, not extracted from blood or biologics.

What makes the combination so effective?

CoolPeel creates precise microchannels in the skin, temporarily opening pathways that allow topical actives to absorb far more deeply than they would on intact skin. When Ariessence PDGF+ is applied immediately after treatment, it penetrates directly to the level where collagen-producing fibroblasts live. PDGF then signals those fibroblasts to accelerate tissue repair, produce new collagen, and reduce inflammation, which is exactly what you want post-resurfacing.

The result is faster healing, reduced redness duration, and significantly enhanced collagen remodeling compared to laser alone. Clients often notice tighter, more hydrated skin within 72 hours, with improvements in texture and tone continuing to build for up to six months as new collagen matures.

Who is this treatment for?

The CoolPeel PDGF treatment is ideal for anyone concerned about fine lines, sun damage, enlarged pores, uneven skin texture, or early signs of skin laxity. It’s also an excellent option for clients concerned about undereye crepiness, fine lines around the eyes, or loose eyelid skin, areas that microneedling simply cannot treat. It’s a strong fit for clients who want real results without extended downtime, and for those who want a treatment protocol backed by clinical data rather than marketing trends.

Most clients complete 1 to 3 sessions spaced 4 to 6 weeks apart, with results that continue to develop over the months following their final session.

Side-by-side comparison

Treatment comparison

Microneedling

Mechanical micro-injuries that trigger wound healing in the dermis. Does not resurface the skin surface.

• How it works: Fine needles puncture the skin at a set depth across the full treatment area, triggering a wound-healing response. Multiple passes required.
• Depth control: Set manually, uniform across the entire face. No ability to vary depth by concern or zone.
• Surface treatment: Does not remove or resurface the outer skin layer. Sun damage, pigmentation, and rough texture respond poorly.
• Collagen stimulation: Stimulates collagen via injury response in the dermis.
• Treatment areas: Face and body can be treated. Cannot treat eyelid or undereye areas.
• Sessions needed: Typically 3 to 6 sessions to achieve optimal results.
• Downtime: 1 to 2 days of redness.

CoolPeel Laser

Fractional CO2 laser that resurfaces the skin surface and stimulates deep collagen simultaneously, in fewer sessions.

• How it works: Precise thermal energy is delivered to the skin in controlled columns, vaporizing damaged surface tissue and stimulating the dermis in a single pass. The technician works with a precise laser beam rather than a needle cartridge, allowing for far greater depth and density control.
• Depth control: Laser parameters including depth, density, and energy are dialed in precisely for each client’s specific concerns. Far greater control than needles allow.
• Surface treatment: Directly resurfaces the outer skin layer. Sun damage, pigmentation, texture, and pore size all respond well.
• Collagen stimulation: Stimulates collagen both from resurfacing and from deep thermal energy. Two mechanisms working together. Ariessence Pure PDGF+ enhances collagen remodeling.
• Treatment areas: Can safely treat face, eyelids, under eyes, and body. Microneedling cannot be performed in eyelid or undereye areas.
• Sessions needed: Typically 1 to 3 sessions. More significant results per session means fewer total treatments.
• Downtime: 1 to 2 days, comparable to microneedling with noticeably stronger results.

Comparison Summary

• CoolPeel sessions needed: 1 to 3
• Microneedling sessions needed: 3 to 6
• CoolPeel downtime: 1-2 days
• Microneedling downtime: 1-2 days

CoolPeel resurfaces and rebuilds at the same time. Microneedling only rebuilds. Same recovery, more results, fewer appointments.

If your concerns include texture, pore size, sun damage, fine lines, or dull tone, CoolPeel is the more targeted and efficient choice. It resurfaces the outer skin layer while stimulating deep collagen, two jobs in one treatment. Microneedling triggers healing but leaves surface damage untouched. With the same 1-2 days of downtime and fewer sessions needed, CoolPeel delivers more for less.

What to expect

Consultation and skin assessment. We evaluate your skin concerns, review your medical history, and build a personalized treatment plan. Most clients are scheduled for 1 to 3 sessions, 4 to 6 weeks apart. A consultation is required prior to treatment.

At your appointment:

1. Topical numbing: A topical anesthetic is applied to the treatment area for 30 minutes before the procedure begins, ensuring a comfortable experience.
2. CoolPeel laser resurfacing: The fractional CO2 laser passes over the skin, creating precise microchannels that stimulate the skin’s natural repair process and address texture, tone, and fine lines. Comfort level 1 out of 10 (you will feel 0-1 a little warmth).
3. Ariessence PDGF+ application: Immediately following the laser, Ariessence Pure PDGF+ is applied to the treated skin. The open microchannels allow deep absorption, delivering PDGF directly to fibroblasts where it signals accelerated collagen production and tissue repair.

Recovery: 1-2 days: Mild redness and warmth are normal. Most clients feel comfortable resuming daily activities within 24 hours.

Results build over weeks and months: Immediate improvements in texture, firmness, and tone, with results continuing to build for several weeks as new collagen matures.

Here is a treatment in action:

Results

Pricing

One Treatment: CoolPeel + PDGF: $1,050

• CoolPeel fractional CO2 resurfacing
• Ariessence Pure PDGF+ application
• Best for first-time clients or one-time refresh

Series of 3: CoolPeel + PDGF series: $2,850

• 3 CoolPeel sessions (spaced 4–6 weeks)
• Ariessence PDGF+ at each session
• Personalized treatment plan
• Recommended for optimal collagen remodeling results over 4–6 months.

Frequently asked questions

How is CoolPeel different from microneedling?

CoolPeel is a fractional CO2 laser that simultaneously resurfaces the outer skin layer and stimulates deep collagen. Microneedling uses fine needles to create micro-injuries in the dermis, triggering wound healing, but it does not resurface the skin surface. That means microneedling cannot directly address sun damage, rough texture, or enlarged pores the way CoolPeel can. CoolPeel also delivers more precise, adjustable depth control compared to a needle cartridge set to a fixed depth. Most clients need 1 to 3 CoolPeel sessions versus 3 to 6 sessions with microneedling, with comparable downtime of 1 to 2 days.

Is there a blood draw with CoolPeel + Ariessence PDGF+?

No. Unlike PRP and PRF treatments, CoolPeel + Ariessence PDGF+ requires no blood draw at all. Ariessence is a pharmaceutical-grade growth factor made in a controlled lab environment. It contains the same platelet-derived growth factor (PDGF) naturally found in your blood, but produced through recombinant technology for consistent potency and purity in every vial. This means shorter appointments, a more comfortable experience, and no variability based on your blood composition that day.

What is PDGF and why does it matter for skin?

PDGF stands for platelet-derived growth factor. It is a naturally occurring protein found in human blood and platelets that signals the body to produce new collagen, repair tissue, and reduce inflammation. What makes Ariessence unique is that it contains an FDA-approved form of PDGF, the first and only of its kind in the aesthetics industry. The same growth factor has been used in four FDA-approved medical products over 28 years, with more than 5.5 million patients treated. When applied to skin immediately after CoolPeel resurfacing, PDGF penetrates deeply through the open microchannels and accelerates the healing and collagen-building process significantly.

How is Ariessence PDGF+ different from exosomes?

Exosomes are promising in research, but they are currently unregulated in the aesthetics market. The source, purity, and growth factor concentration of exosome products vary widely between brands and even between batches of the same product. There is no standardization, and the FDA has raised concerns about unapproved exosome products being marketed for aesthetic use. Ariessence is different. It contains a single, known, FDA-approved growth factor produced in a pharmaceutical-grade lab with the same concentration in every vial. Four ingredients, no unknowns, and a 28-year safety record behind the active ingredient.

What is the downtime after CoolPeel?

Most clients experience 1 to 2 days of mild redness and warmth following CoolPeel. This is comparable to the downtime from microneedling. Many clients feel comfortable resuming their normal daily activities within 24 hours. We recommend avoiding direct sun exposure and following the post-care protocol provided at your appointment. The addition of Ariessence PDGF+ may also help reduce redness duration by accelerating the skin’s repair process.

How many sessions will I need?

Most clients complete 1 to 3 sessions spaced 4 to 6 weeks apart, depending on their skin concerns and goals. A single session can produce meaningful improvements in texture, tone, and radiance. A series of 3 sessions is recommended for clients with more significant concerns such as deeper sun damage, fine lines, or acne scarring, as collagen remodeling continues to build for up to 6 months after the final session. We build a personalized plan during your consultation.

Who is a good candidate for CoolPeel PDGF Treatment?

This treatment is an excellent fit for anyone concerned about fine lines, sun damage, uneven skin texture, enlarged pores, dull tone, or early skin laxity. CoolPeel on the Helix platform is safe for all skin types. The Helix allows our providers to customize laser settings to accommodate every Fitzpatrick skin type safely and effectively. This is a meaningful difference from older CO2 laser platforms, which carried higher risk for deeper skin tones. If you have questions about how we approach your specific skin tone, we are happy to discuss that during your complimentary consultation. CoolPeel is also a strong option for clients who want real resurfacing results without the variability of blood-based treatments or the unknowns of unregulated exosome products.

Is CoolPeel safe for my skin tone?

Yes. CoolPeel at Renew MedSpa is safe for all skin types and skin tones. We use the Helix platform, which gives our providers precise control over treatment settings. This allows us to tailor every treatment to your specific skin tone, reducing the risk of irritation or pigmentation changes that can be a concern with older CO2 laser technology. Whether you have a fair complexion or a deeper skin tone, we customize your treatment to work safely and effectively for you. We will always assess your skin during your consultation and build a plan that fits your unique needs.

When will I see results?

Many clients notice improved hydration and radiance within 72 hours as their skin heals. More significant improvements in texture, firmness, and tone develop over the following 4 to 6 weeks as new collagen matures. With a full series of 3 sessions, results continue to build for up to 6 months after the last treatment. The combination of CoolPeel resurfacing and Ariessence PDGF+ is designed to accelerate and enhance the body’s natural collagen production, so results improve over time rather than peaking immediately after treatment.

Is CoolPeel and Ariessence PDGF+ better than microneedling with PRP?

For most clients, yes. CoolPeel resurfaces the skin surface while stimulating collagen, two mechanisms working together. Microneedling with PRP only stimulates collagen and leaves surface damage like sun spots, rough texture, and pore size untreated. PRP also depends on the quality of your blood that day, meaning results can vary between sessions based on stress, hydration, medications, and age. Ariessence PDGF+ delivers the same pharmaceutical-grade concentration every time, with no blood draw required. The result is more predictable outcomes, fewer sessions needed, and a more comfortable appointment overall.

Can CoolPeel treat the undereye and eyelid areas?

Yes, and this is one of the most significant advantages CoolPeel has over microneedling. The Helix CO2 laser can safely and precisely treat the undereye and eyelid areas, targeting crepiness, fine lines, and loose skin in zones that microneedling cannot reach. Needles cannot be used safely around the orbital area, making microneedling off-limits for these concerns entirely. CoolPeel’s fractional laser technology allows our providers to dial in the exact depth and density appropriate for the delicate skin around the eyes, delivering real improvement in some of the most visible signs of aging, without surgery and with just 1 to 2 days of downtime.

Does the person performing my treatment matter?

Absolutely. The technology is only part of the story. The person behind the device matters just as much. Our providers bring clinical expertise and a thorough understanding of how different skin types and skin concerns respond to laser energy, so your settings are never guessed at. You can expect a treatment plan built around your skin, not a one-size-fits-all protocol. We assess your skin carefully during your consultation and adjust at every session based on how your skin responds.

Ready to experience the difference and get better results?

Book a consultation at Renew MedSpa